Shopping Cart
Sorry, that code is not valid for your order. Try a different code.
Discount Applied
Military, First Responder, Government Employee and Teacher discounts available. Verify with GovX ID to unlock your savings.
Limited Time 4th of July Sale:
20% off sitewide, use code USA20
[{"product_name":"Focus","shopify_variant_id":"5531","variant_name":"Single Bottle","variant_price":"87","product_thumbnail":"https:\/\/\/wp-content\/uploads\/2023\/08\/Blokes-_-Joi-Focus-FRONT.png","url":"\/product\/focus\/","selling_plan_id":""},{"product_name":"Metabolic","shopify_variant_id":"5548","variant_name":"Single Bottle","variant_price":"87","product_thumbnail":"https:\/\/\/wp-content\/uploads\/2023\/08\/Blokes-_-Joi-Metabolic-FRONT-1.png","url":"\/product\/metabolic\/","selling_plan_id":""},{"product_name":"Sleep","shopify_variant_id":"5569","variant_name":"Single Bottle","variant_price":"87","product_thumbnail":"https:\/\/\/wp-content\/uploads\/2023\/08\/Sleep-Front-New.png","url":"\/product\/sleep\/","selling_plan_id":""},{"product_name":"Balance","shopify_variant_id":"5520","variant_name":"Single Bottle","variant_price":"87","product_thumbnail":"https:\/\/\/wp-content\/uploads\/2023\/08\/Blokes-_-Joi-Balance-FRONT.png","url":"\/product\/balance\/","selling_plan_id":""}]
[{"reviewer_name":"Kelsey Heenan","review_text":"\"Not only did I see my biomarkers improve, I know I\u2019m taking exactly what my body needs for better performance and better day to day life.\"","reviewer_image":"https:\/\/\/wp-content\/uploads\/2024\/03\/Kelsey-H-headshot-1-e1711499030467.jpg"},{"reviewer_name":"Janna Breslin","review_text":"\"I need to be in tune with my body and Joi offers deep dive blood diagnostic labs that allow me to supplement with precision through Smart Supps.\"","reviewer_image":"https:\/\/\/wp-content\/uploads\/2024\/03\/Screenshot-2024-03-26-172513.png"},{"reviewer_name":"Jessica Cooper","review_text":"\"The process with Joi was super easy and customized to fit my needs. I\u2019m busy with 3 kids, a husband and a full-time job so feeling my best and having energy is a must for me!\"","reviewer_image":"https:\/\/\/wp-content\/uploads\/2024\/03\/jessica.jpg"}]

Should I Use Vaginal Estradiol Cream? 

December 5, 2023

Vaginal Estradiol Cream is a medication that is commonly prescribed to women experiencing certain gynecological issues related to low estrogen levels. This hormone replacement therapy (HRT) is designed to address a range of symptoms, but it's essential to weigh its effectiveness, benefits, and potential drawbacks before considering its use. In this article, we will explore the key aspects of VE cream, including its effectiveness, what it does, its pros and cons, and potential side effects.

How Effective?

Vaginal Estradiol Cream is generally considered effective for its intended purposes. It contains estradiol, a synthetic form of estrogen, which helps replenish low estrogen levels in the vaginal tissues. This can be particularly beneficial for women going through menopause or experiencing other conditions that lead to vaginal dryness, itching, and discomfort. Estradiol cream effectively addresses these issues by rejuvenating the vaginal lining and restoring its elasticity and moisture.

What Does Vaginal Estradiol Cream Do?

  • Relieves Vaginal Dryness: One of the primary purposes of VE is to combat vaginal dryness, a common symptom of menopause or other hormonal imbalances. By applying the cream directly to the vaginal tissues, it helps to moisturize and restore natural lubrication, alleviating discomfort during sexual activity and daily life.
  • Reduces Vaginal Atrophy: Vaginal atrophy is a condition in which the vaginal tissues become thin, fragile, and less elastic due to estrogen deficiency. Estradiol cream can help reverse this by stimulating the growth of vaginal cells, improving tissue thickness, and reducing the risk of irritation and pain.
  • Treats Recurrent Urinary Tract Infections (UTIs): Some women may experience frequent UTIs due to changes in the vaginal flora. VE Cream can help restore the balance of healthy bacteria in the vaginal environment, potentially reducing the incidence of UTIs.


  • Targeted Relief: Unlike systemic hormone replacement therapy, which affects the entire body, vaginal Estradiol Cream is applied directly to the affected area, providing localized relief with fewer systemic side effects.
  • Improved Quality of Life: Many women find relief from uncomfortable symptoms such as vaginal dryness, itching, and painful intercourse, which can significantly improve their overall quality of life.
  • Customizable Dosage: Physicians can tailor the dosage of vaginal Estradiol Cream to suit individual needs, ensuring that each patient receives the appropriate amount of estrogen for their specific condition.


  • Prescription Required: VE Cream is not available over the counter and requires a prescription from a healthcare provider.
  • Potential Side Effects: Like any medication, VE Cream can have side effects, which may include breast tenderness, nausea, headache, or vaginal spotting. These side effects are usually mild and temporary.
  • Risk of Endometrial Hyperplasia: Women with an intact uterus who use estrogen therapy, including VE Cream, may have an increased risk of endometrial hyperplasia, a precancerous condition of the uterine lining. To mitigate this risk, a progestin hormone may also be prescribed.

Side Effects

Common side effects of Vaginal Estradiol Cream may include breast tenderness, vaginal spotting or discharge, headache, and abdominal pain. It's essential to discuss any concerns or side effects with your healthcare provider promptly.

VE Cream can be an effective treatment option for women experiencing symptoms related to low estrogen levels, such as vaginal dryness and discomfort. However, it is essential to weigh the pros and cons carefully, considering individual medical history and needs. Always consult with a healthcare provider to determine if Vaginal Estradiol Cream is the right choice for you, and follow their guidance for safe and effective use.

Back to Blog
More Thoughts
See all Articles
Schedule Online Consult