We prescribe sirolimus because it is more bioavailable than the compounded version of rapamycin.

Generally, 5mg capsules taken once a week orally. New patients will be titrated up by clinician guidance. Providers may also cycle patients off for a short period of time.

We require a lab to start and then after 3 months of treatment. After that we test annually.

Possible side effects include sore or inflamed mouth, weakened immune system, anemia or fatigue, constipation or diarrhea, elevated lipid levels, high blood pressure, swollen hands or feet. Please contact us on the onset of any symptom you think may be related to treatment.

Rapamycin directly stimulates the cellular cleaning process known as autophagy, effectively clearing toxic debris and promoting cellular rejuvenation.

Cellular senescence is a process that results from a variety of stresses and leads to a state of irreversible growth arrest. Senescent cells accumulate during aging and have been implicated in promoting a variety of age-related diseases.

The mTOR pathway, found in all cells, determines when a cell should grow and divide. However, with time, it can become too active, resulting in unchecked cell growth and compromised tissue health. Rapamycin is a direct inhibitor of the mTOR pathway. Low doses of rapamycin appear to reset mTOR activity to a more youthful state—active when needed and dormant when not required.

Our Joi + Blokes Coaches are here to support you and be a listening ear during your Joi/Blokes experience. Consider them your health journey BFF’s who can help you navigate your results and support you along the way! We know how challenging (and oftentimes isolating) health issues can be, and we want you to know you’re not alone on this path. Our coaches can provide guidance, general information, and most importantly, be your liaison when you need answers from your provider.

Our health coaches’ experience and expertise range from nurses, registered dietitians, personal trainers, naturopathic doctors to navy seals.

Please note: Health Coaches are not doctors and cannot prescribe, provide specific medical advice or diagnose you with any medical conditions.

Joi + Blokes health coaches are here to:

• Listen to your experience – you are not alone!
• Help you understand your results
• Provide information on therapies we offer that may help you meet your goals
• Be your direct contact for any questions you have during your journey, on your order, or for your provider – they are here to help!

All prescription products require a medical consultation with a licensed provider, either asynchronously or synchronously, who will determine if a prescription is appropriate. If not deemed appropriate, you will be immediately refunded.

Email us at info@choosejoi.co with any more questions.