Rapamycin (Sirolimus)
Rapamycin (Sirolimus)

Rapamycin (Sirolimus)

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Rapamycin is considered to be one of the most promising healthspan-promoting therapies for its role in slowing down the formation of senescent cells through its inhibition of the mTOR complex I pathway.

Taken in small doses over an extended period of time, Rapamycin supports processes that preserve cellular health with age, leading to a longer period of life spent active and with less dysfunction.

Choose a lab to get started:

  • Promote a longer and healthier lifespan
  • Delay the onset of age-related diseases
  • Improve metabolic health
  • Strengthen immune function
  • Help boost overall energy levels
  • Improve skin health
What's Included?
Board Certified Clinicians
Lifestyle & Nutrition Support
Unlimited Messaging
1:1 Coaching
Doctor Prescribed Medications
Access to Labs & Supplements
We're with you every step of the way.

Complete the online health history and consent forms

Fill out the online health history and consent forms or contact your coach if you are a current patient.

Lab Work

Complete a lab or share one you've done within the last 90 days.

Shipped to your door

A clinician will go over your health history and goals to ensure you are a candidate. If approved, your medication will be shipped to your door.

Ongoing Care

We will schedule a lab draw & follow-up visit after the 3rd month of treatment. After that, quarterly check-ins with annual lab draws.

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What is sirolimus?

We prescribe sirolimus because it is more bioavailable than the compounded version of rapamycin.

What is the rapamycin anti-aging protocol?

Generally, 5mg capsules taken once a week orally. New patients will be titrated up by clinician guidance. Providers may also cycle patients off for a short period of time.

Do I need labs to be on treatment?

We require a lab to start and then after 3 months of treatment. After that we test annually.

What are the side effects?

Possible side effects include sore or inflamed mouth, weakened immune system, anemia or fatigue, constipation or diarrhea, elevated lipid levels, high blood pressure, swollen hands or feet. Please contact us on the onset of any symptom you think may be related to treatment.

What is autophagy?

Rapamycin directly stimulates the cellular cleaning process known as autophagy, effectively clearing toxic debris and promoting cellular rejuvenation.

What is cellular senescence?

Cellular senescence is a process that results from a variety of stresses and leads to a state of irreversible growth arrest. Senescent cells accumulate during aging and have been implicated in promoting a variety of age-related diseases.

What is the mTOR pathway?

The mTOR pathway, found in all cells, determines when a cell should grow and divide. However, with time, it can become too active, resulting in unchecked cell growth and compromised tissue health. Rapamycin is a direct inhibitor of the mTOR pathway. Low doses of rapamycin appear to reset mTOR activity to a more youthful state—active when needed and dormant when not required.

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