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Dr. Andrew Weil on Hormone Replacement Therapy: Is It Safe for Women?

October 19, 2023

Hormone Replacement Therapy (HRT) has been a topic of debate and concern for many years, especially when considering its long-term effects on women. Dr. Andrew Weil, a renowned integrative medicine expert, has weighed in on the subject, providing insights and recommendations based on scientific research and clinical observations.

Dr. Weil's Perspective on HRT

According to an article by Dr. Weil, long-term use of HRT, specifically the combination of estrogen and progesterone, has been linked to an increased risk of breast cancer. A study involving about 60,000 nurses found that taking HRT for 10 to 14.9 years increased the risk of breast cancer by 88%. The risk more than doubled for women who took the hormones in combination for 15 to 19.9 years. Furthermore, using estrogen alone increased breast cancer risk by 22% when used from 10 to 14.9 years and by 43% when used from 15 to 19.9 years.

However, it's essential to differentiate between relative risk and absolute risk. While the relative risk might seem alarming, the absolute risk paints a different picture. For instance, if the typical chance of developing breast cancer was one woman in 100, an 88% increase would mean that breast cancer would occur in 1.88 women out of 100. This means that 98.12 women out of 100 would not get the disease.

Despite these findings, Dr. Weil suggests that women should consider weaning off HRT and explore alternative remedies to manage menopausal symptoms. He recommends natural remedies like black cohosh and whole soy foods, which have shown promise in reducing hot flashes and other menopausal symptoms.

The WHI Study and Synthetic Progesterone

The Women's Health Initiative (WHI) study is a significant point of reference when discussing HRT. This study aimed to understand the benefits and risks of HRT better. However, one of the significant criticisms of the WHI study was its design and participant selection. The use of synthetic progesterone in the WHI study was particularly problematic. Synthetic progesterone, unlike its natural counterpart, has been linked to increased risks, further complicating the understanding of HRT's safety.

Hormones and the Menstruation Cycle

Hormones play a crucial role in a woman's menstrual cycle. Estrogen levels rise during the first half of the cycle, preparing the body for ovulation. Post ovulation, progesterone dominates, preparing the uterus for a potential pregnancy. If pregnancy doesn't occur, both hormone levels drop, leading to menstruation. This cycle is also associated with various symptoms, including PMS, which is linked to the rapid reduction of progesterone in the latter half of the cycle.

Dr. Peter Attia's Insights

Dr. Peter Attia, in a discussion on the Huberman Lab Podcast, delved deep into the topic of HRT for women. He emphasized the importance of understanding the biology of estrogen and progesterone in the female body. He highlighted that while estrogen is phenotypically dominant in women, in absolute amounts, women have more testosterone than estrogen. This understanding is crucial when considering hormone therapies.

Dr. Attia also discussed the implications of giving women estrogen without progesterone, which led to an increased risk of uterine cancer. This realization underscored the importance of a balanced approach to Hormone Replacement Therapy.

Pros and Cons of HRT for Women

Based on the National Health Institute article:


Bone Health: Long-term hormone therapy can prevent bone fractures.

Potential Reduction in Bowel Cancer Risk: Some studies suggest that hormone therapy could lower the risk of bowel cancer.


Increased Risk of Serious Diseases: These include strokes, heart attacks, blood clots, and breast cancer.

Potential for Dementia: Women who undergo long-term hormone therapy might have a higher risk of developing dementia.

While HRT can offer relief from menopausal symptoms, it's essential to be aware of its potential risks. Both Dr. Weil and Dr. Attia emphasize the importance of individualized care, understanding the nuances of hormone therapy, and making informed decisions based on comprehensive research and consultation with healthcare professionals.

This is why we believe it’s important to complete diagnostic labs and work with professionals to determine whether or not hormone replacement therapy is the right option for you. For people concerned about HRT side effects - there are a number of ways you can change your diet and lifestyle behaviors to also impact your hormone balances. 

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